Advantages of immune complex vaccines based on IgY of egg origin for the prevention of Infectious Bursal Disease

Immune complex vaccines against Infectious bursal disease virus (IBDV) are formulated by mixing attenuated virus of a Infectious bursal disease and a solution of specific antibodies against the same virus (IgY) that will coat the vaccine virus. The complex formed (virus and antibodies) will protect the vaccine from its neutralization.

From the first immune complex vaccines developed in the 1990s until now, all of them have used specific IgY extracted from the serum of hyperimmunized animals as coating antibodies (Figure 1).

Basis of the immune-complex IBDV vaccines formulation Figure 1. Basis of the immune complex IBDV vaccines formulation.

A newly formulated immune complex vaccine has now appeared on the market, GUMBOHATCH®, which uses specific IgY extracted from eggs instead of IgY from serum.

But what are the main advantages behind this new formulation?

Discover them in the following video:

A new procedure for extracting the IgY from eggs has been developed in order to improve the consistency and capacity for production of the highest quality antibodies.

The extraction of antibodies from egg yolks has many advantages compared to extraction from the serum. Since the antibodies are extracted from the yolks of laid eggs, the method of antibody production is non-invasive.

Besides, through appropriate immunization strategies, the concentration of antibodies in the egg yolk can be maintained at optimal levels over time.

This process, therefore, prevents the animals from bleeding and stress whilst it allows the harvest of large amounts of antibodies.

The possibility of obtaining large quantities of IgY through extraction from eggs has changed the way of formulating immune complex vaccines, giving the possibility of adding high proportions of IgY to ensure a complete coating of all the virus particles.

Basic Personal Data Protection information:

Purposes: Managing the contractual and/or business relationship with HIPRA, including sending news, promotions and invitations to events sponsored by HIPRA.
Lawful basis: Performance of the contractual relationship and HIPRA’s legitimate Interest.
Recipients: Third parties to which HIPRA has entrusted cloud computing, security, auditing, mailing, technical and computer support services, as well as companies in its group.
Rights: Request access to and rectification or erasure of personal data and other rights as explained in the additional information. You can seeview the detailed additional information about data protection in our Privacy Policy.

For further information, please check our detailed information on Data Protection.

Website for veterinarians

The contents of this website are aimed exclusively at prescribing veterinarians. By clicking on Accept you state that you are a veterinary professional. In other case, please contact a veterinarian and click on Decline.